You can:
Name | D(4) dopamine receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | DRD4 |
Synonym | D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor |
Disease | Erectile dysfunction Psychotic disorders Schizophrenia |
Length | 467 |
Amino acid sequence | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC |
UniProt | P21917 |
Protein Data Bank | 5wiv, 5wiu |
GPCR-HGmod model | P21917 |
3D structure model | This structure is from PDB ID 5wiv. |
BioLiP | BL0394824, BL0394826, BL0394825 |
Therapeutic Target Database | T24983 |
ChEMBL | CHEMBL219 |
IUPHAR | 217 |
DrugBank | BE0009376, BE0000389 |
Name | BENPERIDOL |
---|---|
Molecular formula | C22H24FN3O2 |
IUPAC name | 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1H-benzimidazol-2-one |
Molecular weight | 381.451 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.7 |
Synonyms | 2-Benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl)- FT-0634013 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro- HMS3374B03 4'-Fluor-4-(4-(2-oxo-1-benzimidazolinyl)piperidino)butyrophenon [ Show all ] |
Inchi Key | FEBOTPHFXYHVPL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) |
PubChem CID | 16363 |
ChEMBL | CHEMBL297302 |
IUPHAR | 9215 |
BindingDB | 81492, 50183266 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.066 nM | PMID27364609 | BindingDB |
Ki | 0.066 nM | PMID9577836 | IUPHAR |
Ki | 0.066 nM | PMID9577836, PMID27364609 | PDSP,BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417