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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasopressin V2 receptor
Species	Bos taurus (Bovine)
Gene	AVPR2
Synonym	Antidiuretic hormone receptor AVPR V2 Renal-type arginine vasopressin receptor V2R
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MFMASTTSAVPWHLSQPTPAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDVDGSGVLDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLGPGPVPRAGGPRRGCRPGSPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQEESCATASSFLAKDTPS
UniProt	P48044
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2344
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL415230
Molecular formula	C48H76N14O12S2
IUPAC name	(10S,13S,16S,19S,22S)-13-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-16-(3-amino-3-oxopropyl)-19-[(2S)-butan-2-yl]-22-[(4-ethoxyphenyl)methyl]-N-methyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carboxamide
Molecular weight	1105.34
Hydrogen bond acceptor	15
Hydrogen bond donor	12
XlogP	-2.5
Synonyms	BDBM50030085 [Mpa1,D-Tyr(OEt)2,Sar7]AVT
Inchi Key	FDTWFAPCNBHZFJ-ORUCKJHKSA-N
Inchi ID	InChI=1S/C48H76N14O12S2/c1-5-27(3)40-45(72)58-31(16-17-35(49)63)42(69)59-33(22-36(50)64)43(70)60-34(46(73)62(4)25-39(67)56-30(11-10-20-54-47(52)53)41(68)55-24-37(51)65)26-75-76-48(18-8-7-9-19-48)23-38(66)57-32(44(71)61-40)21-28-12-14-29(15-13-28)74-6-2/h12-15,27,30-34,40H,5-11,16-26H2,1-4H3,(H2,49,63)(H2,50,64)(H2,51,65)(H,55,68)(H,56,67)(H,57,66)(H,58,72)(H,59,69)(H,60,70)(H,61,71)(H4,52,53,54)/t27-,30-,31-,32-,33-,34+,40-/m0/s1
PubChem CID	44321188
ChEMBL	CHEMBL415230
IUPHAR	N/A
BindingDB	50030085
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kd	35.0 nM	PMID7507528	BindingDB,ChEMBL

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