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GPCR

NameC-C chemokine receptor type 2
SpeciesHomo sapiens (Human)
GeneCCR2
SynonymMCP-1-R
Monocyte chemoattractant protein 1 receptor
CKR2
MCP-1 receptor
chemokine receptor CCR2
[ Show all ]
DiseaseChronic obstructive pulmonary disease
Neuropathic pain
Multiple scierosis
Metastatic cancer; Multiple scierosis
Inflammatory disease
[ Show all ]
Length374
Amino acid sequenceMLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
UniProtP41597
Protein Data Bank6gpx, 6gps
GPCR-HGmod modelP41597
3D structure modelThis structure is from PDB ID 6gpx.
BioLiPBL0437328,BL0437329, BL0437327, BL0437326, BL0437325
Therapeutic Target DatabaseT89988
ChEMBLCHEMBL4015
IUPHAR59
DrugBankN/A

Ligand

NameCID 136859397
Molecular formulaC43H32N10Na4O17S4
IUPAC nametetrasodium;4-[[1-methyl-4-[[4-[[[[5-[[1-methyl-5-[(8-sulfo-4-sulfonatonaphthalen-1-yl)carbamoyl]pyrrol-3-yl]carbamoyl]-1H-pyrrol-3-yl]amino]-oxidomethylidene]amino]-1H-pyrrole-2-carbonyl]amino]pyrrole-2-carbonyl]amino]naphthalene-1,5-disulfonate
Molecular weight1180.98
Hydrogen bond acceptor18
Hydrogen bond donor8
XlogPNone
SynonymsN/A
Inchi KeyABDIWGRATHZIPB-UHFFFAOYSA-J
Inchi IDInChI=1S/C43H36N10O17S4.4Na/c1-52-19-23(15-31(52)41(56)50-27-9-11-33(71(59,60)61)25-5-3-7-35(37(25)27)73(65,66)67)46-39(54)29-13-21(17-44-29)48-43(58)49-22-14-30(45-18-22)40(55)47-24-16-32(53(2)20-24)42(57)51-28-10-12-34(72(62,63)64)26-6-4-8-36(38(26)28)74(68,69)70;;;;/h3-20,44-45H,1-2H3,(H,46,54)(H,47,55)(H,50,56)(H,51,57)(H2,48,49,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70);;;;/q;4*+1/p-4
PubChem CID136859397
ChEMBLCHEMBL264470
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition5.4 %PMID9632350ChEMBL

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