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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 6
Species	Homo sapiens (Human)
Gene	P2RY6
Synonym	pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	328
Amino acid sequence	MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
UniProt	Q15077
Protein Data Bank	N/A
GPCR-HGmod model	Q15077
3D structure model	This predicted structure model is from GPCR-EXP Q15077.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4714
IUPHAR	326
DrugBank	N/A

Ligand

Name	CHEMBL1199952
Molecular formula	C12H18N2O11P2S
IUPAC name	[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-prop-2-enylsulfanylpyrimidin-1-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight	460.287
Hydrogen bond acceptor	12
Hydrogen bond donor	5
XlogP	-2.4
Synonyms	(2R,3R,4S,5R)-4-(allylthio)-1-(3,4-dihydroxy-5-(diphosphoryloxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one ammonium salt BDBM50194148
Inchi Key	FCNUIFOCIBZHHC-QCNRFFRDSA-N
Inchi ID	InChI=1S/C12H18N2O11P2S/c1-2-5-28-8-3-4-14(12(17)13-8)11-10(16)9(15)7(24-11)6-23-27(21,22)25-26(18,19)20/h2-4,7,9-11,15-16H,1,5-6H2,(H,21,22)(H2,18,19,20)/t7-,9-,10-,11-/m1/s1
PubChem CID	16082739
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50194148
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	560.0 nM	PMID16942026	BindingDB

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