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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL137570
Molecular formula	C22H23NO3
IUPAC name	2-methyl-6-(4-phenylquinolin-2-yl)oxyhexanoic acid
Molecular weight	349.43
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	6-[(4-Phenylquinolin-2-yl)oxy]-2-methylhexanoic acid 2-Methyl-6-(4-phenyl-quinolin-2-yloxy)-hexanoic acid BDBM50001615
Inchi Key	FCBKQQQUBFIBRZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23NO3/c1-16(22(24)25)9-7-8-14-26-21-15-19(17-10-3-2-4-11-17)18-12-5-6-13-20(18)23-21/h2-6,10-13,15-16H,7-9,14H2,1H3,(H,24,25)
PubChem CID	10247237
ChEMBL	CHEMBL137570
IUPHAR	N/A
BindingDB	50001615
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	550.0 nM	PMID1333011	BindingDB,ChEMBL

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