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Name | D(4) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD4 |
Synonym | D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor |
Disease | Erectile dysfunction Psychotic disorders Schizophrenia |
Length | 467 |
Amino acid sequence | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC |
UniProt | P21917 |
Protein Data Bank | 5wiv, 5wiu |
GPCR-HGmod model | P21917 |
3D structure model | This structure is from PDB ID 5wiv. |
BioLiP | BL0394824, BL0394826, BL0394825 |
Therapeutic Target Database | T24983 |
ChEMBL | CHEMBL219 |
IUPHAR | 217 |
DrugBank | BE0009376, BE0000389 |
Name | CHEMBL460542 |
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Molecular formula | C29H31F2N3O2 |
IUPAC name | 1-[4-(3,4-difluorophenyl)piperazin-1-yl]-3-[methyl-[2-(9H-xanthen-9-yl)ethyl]amino]propan-1-one |
Molecular weight | 491.583 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 4.9 |
Synonyms | 3-((2-(9H-xanthen-9-yl)ethyl)(methyl)amino)-1-(4-(3,4-difluorophenyl)piperazin-1-yl)propan-1-one BDBM50248555 SCHEMBL5342610 |
Inchi Key | FBLFUQVNJABTNK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H31F2N3O2/c1-32(14-12-22-23-6-2-4-8-27(23)36-28-9-5-3-7-24(22)28)15-13-29(35)34-18-16-33(17-19-34)21-10-11-25(30)26(31)20-21/h2-11,20,22H,12-19H2,1H3 |
PubChem CID | 17955460 |
ChEMBL | CHEMBL460542 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 489.78 nM | PMID19208473 | ChEMBL |
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