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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Bos taurus (Bovine)
Gene	DRD2
Synonym	Dopamine D2 receptor
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P20288
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3998
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	pramipexole
Molecular formula	C10H17N3S
IUPAC name	(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Molecular weight	211.327
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.9
Synonyms	104632-26-0 Pramipexole Teva 632P260 SC-46343 AB0055235 SpecPlus_000820 CAS-104632-26-0 SUD-919CL2Y CX1349 ZINC3781664 DSSTox_CID_3496 HMS2051A21 KBio2_002340 (-) Pramipexole Mirapexin (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole NCGC00167441-03 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)- Pramipexolum A801025 Sifrol(TN) AK-55454 SR-01000763219 SY009549 DB-038042 DTXSID6023496 HSDB 8253 KBioSS_002343 (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine MLS001423952 (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Pramipexol [Spanish] Pramipexole (USAN/INN) 2-amino-6-propylaminotetrahydrobenzothiazole s2460 AB00053772_14 SND-919 BDBM50116766 ST24036373 CS-2510 U-98528E DivK1c_006916 FT-0651622 K-0425 Mirapex (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine NCGC00167441-01 (S)-Pramipexole 111GE001 Pramipexole [USAN:INN:BAN] 83619PEU5T SCHEMBL35376 AC1L3P1T Spectrum5_001453 CCG-100823 SUD919CL2Y D05575 DSSTox_GSID_23496 HMS2090C15 KBio2_004908 (-)-Pramipexole Mirapexin (TN) (s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole Oprymea 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)- Pramipexolum [Latin] AB00053772-12 SMR000449298 ANW-64032 SR-01000763219-5 CHEMBL301265 Tox21_112445 EC 600-593-1 HY-B0410 KS-00000A3W (6S)-N'-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine MolPort-003-849-957 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine Pramipexole Base SAM001247006 AB00053772_16 SND-919CL2Y BIDD:GT0250 SUD 919CL2Y CTK8C0068 UNII-83619PEU5T DS-14807 GTPL953 KBio1_001860 Mirapex (TN) (s)-(-)-2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole NCGC00167441-02 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperaziny 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)- Pramipexole [USAN:INN] Sifrol AJ-45593 Spectrum_001838 CHEBI:8356 SW197453-4 D0G8NN DSSTox_RID_77054 HMS2232B03 KBio2_007476 (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine MLS000758250 (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;(S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole Pramipexol Pramipexole (Mirapex) 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole RT-015572 AB00053772-13 SND 919 B1488 SR-01000763219-6 CPD000449298 Tox21_112445_1 DB00413 FASDKYOPVNHBLU-ZETCQYMHSA-N J-001211 LS-40722 (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine NC00073 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine [ Show all ]
Inchi Key	FASDKYOPVNHBLU-ZETCQYMHSA-N
Inchi ID	InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1
PubChem CID	119570
ChEMBL	CHEMBL301265
IUPHAR	953
BindingDB	50116766
DrugBank	DB00413
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	1.6 nM	PMID12161137	BindingDB,ChEMBL

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