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GPCR

NameSubstance-P receptor
SpeciesHomo sapiens (Human)
GeneTACR1
SynonymNK-1 receptor
Tachykinin receptor 1
TAC1R
SPR
Substance P receptor
[ Show all ]
DiseaseCough
Depression
Depression; Anxiety
Diabetes
Eczema
[ Show all ]
Length407
Amino acid sequenceMDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
UniProtP25103
Protein Data Bank2ksa, 6e59, 6hlo, 2ks9, 6hlp, 6hll, 2ksb
GPCR-HGmod modelP25103
3D structure modelThis structure is from PDB ID 2ksa.
BioLiPBL0101802, BL0437915, BL0437914, BL0437913, BL0434896, BL0101803, BL0101801
Therapeutic Target DatabaseT47094
ChEMBLCHEMBL249
IUPHAR360
DrugBankBE0000384

Ligand

NameCHEMBL2112245
Molecular formulaC74H92FN15O17S2
IUPAC name(4S,7S,10S,13S,16S,19S,22R,25S,28S,31S,34S,37R)-37-amino-34-(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-19-[(4-fluorophenyl)methyl]-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid
Molecular weight1546.76
Hydrogen bond acceptor22
Hydrogen bond donor19
XlogP-0.3
SynonymsBDBM50409026
Inchi KeyAJVHBIHBNFGOHB-BZDRKYDISA-N
Inchi IDInChI=1S/C74H92FN15O17S2/c1-40(92)61-72(104)86-55(32-44-20-10-5-11-21-44)70(102)90-62(41(2)93)73(105)87-58(37-91)71(103)88-59(74(106)107)39-109-108-38-49(77)63(95)80-51(24-14-15-29-76)64(96)85-57(35-60(78)94)68(100)82-52(30-42-16-6-3-7-17-42)65(97)81-53(31-43-18-8-4-9-19-43)66(98)84-56(34-46-36-79-50-23-13-12-22-48(46)50)67(99)83-54(69(101)89-61)33-45-25-27-47(75)28-26-45/h3-13,16-23,25-28,36,40-41,49,51-59,61-62,79,91-93H,14-15,24,29-35,37-39,76-77H2,1-2H3,(H2,78,94)(H,80,95)(H,81,97)(H,82,100)(H,83,99)(H,84,98)(H,85,96)(H,86,104)(H,87,105)(H,88,103)(H,89,101)(H,90,102)(H,106,107)/t40-,41-,49+,51+,52+,53+,54+,55+,56-,57+,58+,59-,61+,62+/m1/s1
PubChem CID71458000
ChEMBLCHEMBL2112245
IUPHARN/A
BindingDB50409026
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50250.0 nMPMID11052787BindingDB,ChEMBL
IC50260.0 nMPMID11052787BindingDB,ChEMBL
IC50900.0 nMPMID11052787BindingDB,ChEMBL
IC509600.0 nMPMID11052787BindingDB,ChEMBL
Inhibition37.0 %PMID11052787ChEMBL

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