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Name | Follicle-stimulating hormone receptor |
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Species | Homo sapiens (Human) |
Gene | FSHR |
Synonym | Follitropin receptor FSH receptor FSH-R LGR1 |
Disease | Female infertility African trypanosomiasis Contraception Ovarian cancer |
Length | 695 |
Amino acid sequence | MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN |
UniProt | P23945 |
Protein Data Bank | 4mqw |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4mqw. |
BioLiP | BL0274372 |
Therapeutic Target Database | T68334 |
ChEMBL | CHEMBL2024 |
IUPHAR | N/A |
DrugBank | BE0000387 |
Name | CHEMBL3263662 |
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Molecular formula | C29H35N5O5S |
IUPAC name | 3-(furan-2-ylsulfonylamino)-4-[4-(2-methylphenyl)piperazin-1-yl]-N-[3-(2-oxopyrrolidin-1-yl)propyl]benzamide |
Molecular weight | 565.689 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 3.1 |
Synonyms | SCHEMBL14651539 |
Inchi Key | DVBQUBKNTFHPNJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H35N5O5S/c1-22-7-2-3-8-25(22)32-16-18-33(19-17-32)26-12-11-23(21-24(26)31-40(37,38)28-10-5-20-39-28)29(36)30-13-6-15-34-14-4-9-27(34)35/h2-3,5,7-8,10-12,20-21,31H,4,6,9,13-19H2,1H3,(H,30,36) |
PubChem CID | 71233935 |
ChEMBL | CHEMBL3263662 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 10.0 % | PMID24685543 | ChEMBL |
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