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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL594703
Molecular formula	C22H36N4O19P2
IUPAC name	tert-butyl N-[2-[[(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carbonyl]amino]ethyl]carbamate
Molecular weight	722.487
Hydrogen bond acceptor	19
Hydrogen bond donor	10
XlogP	-5.9
Synonyms	BDBM50304044 [({[(2R,3R,4S,5S,6S)-6-[(2-{[(tert-butoxy)carbonyl]amino}ethyl)carbamoyl]-3,4,5-trihydroxyoxan-2-yl]oxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid
Inchi Key	DUQNIUZYFQKFRA-HSIGMSJXSA-N
Inchi ID	InChI=1S/C22H36N4O19P2/c1-22(2,3)43-21(35)24-6-5-23-17(33)16-13(30)12(29)15(32)19(42-16)44-47(38,39)45-46(36,37)40-8-9-11(28)14(31)18(41-9)26-7-4-10(27)25-20(26)34/h4,7,9,11-16,18-19,28-32H,5-6,8H2,1-3H3,(H,23,33)(H,24,35)(H,36,37)(H,38,39)(H,25,27,34)/t9-,11-,12+,13+,14-,15-,16+,18-,19-/m1/s1
PubChem CID	46226463
ChEMBL	CHEMBL594703
IUPHAR	N/A
BindingDB	50304044
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	951.0 nM	PMID19502066	BindingDB,ChEMBL

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