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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 6
Species	Homo sapiens (Human)
Gene	P2RY6
Synonym	pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	328
Amino acid sequence	MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
UniProt	Q15077
Protein Data Bank	N/A
GPCR-HGmod model	Q15077
3D structure model	This predicted structure model is from GPCR-EXP Q15077.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4714
IUPHAR	326
DrugBank	N/A

Ligand

Name	CHEMBL1083263
Molecular formula	C22H42N3O19P3
IUPAC name	N,N-diethylethanamine;[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy-[hydroxy-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphoryl]oxyphosphoryl]methyl]phosphinic acid
Molecular weight	745.501
Hydrogen bond acceptor	20
Hydrogen bond donor	10
XlogP	None
Synonyms	N/A
Inchi Key	DTSFQIFRPUYTME-WTCMLTMYSA-N
Inchi ID	InChI=1S/C16H27N2O19P3.C6H15N/c19-3-6-9(21)11(23)13(25)15(35-6)36-40(31,32)37-39(29,30)5-38(27,28)33-4-7-10(22)12(24)14(34-7)18-2-1-8(20)17-16(18)26;1-4-7(5-2)6-3/h1-2,6-7,9-15,19,21-25H,3-5H2,(H,27,28)(H,29,30)(H,31,32)(H,17,20,26);4-6H2,1-3H3/t6-,7-,9-,10-,11+,12-,13-,14-,15-;/m1./s1
PubChem CID	46832224
ChEMBL	CHEMBL1083263
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Activity	50.0 %	PMID20446735	ChEMBL
EC50	<10000.0 nM	PMID20446735	ChEMBL

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