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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	CHEMBL1935598
Molecular formula	C20H20FNO4S
IUPAC name	7-(3-fluorophenyl)sulfonyl-1-(methoxymethyl)-1-methyl-3,4-dihydro-2H-[1]benzofuro[2,3-c]pyridine
Molecular weight	389.441
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.7
Synonyms	BDBM50361056 SCHEMBL16551437
Inchi Key	DTFIZXBTCSCPFU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H20FNO4S/c1-20(12-25-2)19-17(8-9-22-20)16-7-6-15(11-18(16)26-19)27(23,24)14-5-3-4-13(21)10-14/h3-7,10-11,22H,8-9,12H2,1-2H3
PubChem CID	57400391
ChEMBL	CHEMBL1935598
IUPHAR	N/A
BindingDB	50361056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	113.0 nM	PMID22153937	BindingDB,ChEMBL

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