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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanocortin receptor 3
Species	Mus musculus (Mouse)
Gene	Mc3r
Synonym	gamma-MSH receptor MC3 receptor MC3-R melanocortin receptor 3
Disease	N/A for non-human GPCRs
Length	323
Amino acid sequence	MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
UniProt	P33033
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4774
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1688108
Molecular formula	C39H50N12O6S
IUPAC name	(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-N-[(6S,9S)-4-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-6-[3-(diaminomethylideneamino)propyl]-3,8-dioxo-1,4,7-thiadiazecan-9-yl]-3-phenylpropanamide
Molecular weight	814.967
Hydrogen bond acceptor	9
Hydrogen bond donor	9
XlogP	0.0
Synonyms	BDBM50339349 (S)-2-acetamido-N-((R)-1-((6S,9S)-4-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-6-(3-guanidinopropyl)-3,8-dioxo-1,4,7-thiadiazecan-9-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-(1H-imidazol-4-yl)propanamide
Inchi Key	DPRUDGOHUWTPRM-KELWCDABSA-N
Inchi ID	InChI=1S/C39H50N12O6S/c1-23(52)47-31(16-27-18-43-22-46-27)37(56)49-30(14-24-8-3-2-4-9-24)36(55)50-32-20-58-21-34(53)51(19-26(48-38(32)57)10-7-13-44-39(41)42)33(35(40)54)15-25-17-45-29-12-6-5-11-28(25)29/h2-6,8-9,11-12,17-18,22,26,30-33,45H,7,10,13-16,19-21H2,1H3,(H2,40,54)(H,43,46)(H,47,52)(H,48,57)(H,49,56)(H,50,55)(H4,41,42,44)/t26-,30+,31-,32+,33-/m0/s1
PubChem CID	53318436
ChEMBL	CHEMBL1688108
IUPHAR	N/A
BindingDB	50339349
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7600.0 nM	PMID21306168	BindingDB,ChEMBL

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