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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL485227
Molecular formulaC26H36N2O
IUPAC nameN-[4-[cyclohexyl(propyl)amino]butyl]-4-phenylbenzamide
Molecular weight392.587
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.3
SynonymsBDBM50274411
N-[(N''-(4-Cyclohexyl)-N''-propyl)aminobutyl]-4-biphenylcarboxamide
Inchi KeyDPLNSFBAHKTNGS-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H36N2O/c1-2-20-28(25-13-7-4-8-14-25)21-10-9-19-27-26(29)24-17-15-23(16-18-24)22-11-5-3-6-12-22/h3,5-6,11-12,15-18,25H,2,4,7-10,13-14,19-21H2,1H3,(H,27,29)
PubChem CID25139481
ChEMBLCHEMBL485227
IUPHARN/A
BindingDB50274411
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki670.0 nMPMID18834111BindingDB,ChEMBL

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