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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Relaxin receptor 1
Species	Homo sapiens (Human)
Gene	RXFP1
Synonym	Relaxin family peptide receptor 1 RX1 relaxin/insulin like family peptide receptor 1 relaxin receptor 1 RXFPR1 LGR7 leucine-rich repeat-containing G-protein-coupled receptor 7 Leucine-rich repeat-containing G-protein coupled receptor 7 RXFP1 [ Show all ]
Disease	Acute heart failure
Length	757
Amino acid sequence	MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
UniProt	Q9HBX9
Protein Data Bank	2jm4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jm4.
BioLiP	BL0101296
Therapeutic Target Database	T73696
ChEMBL	CHEMBL1293316
IUPHAR	351
DrugBank	N/A

Ligand

Name	AC1NPW2S
Molecular formula	C14H11BrCl2N2O3
IUPAC name	(7-bromo-4-oxopyrido[1,2-a]pyrimidin-2-yl)methyl 2,2-dichloro-1-methylcyclopropane-1-carboxylate
Molecular weight	406.057
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	1.9
Synonyms	SMR000354021 CHEMBL1433143 (7-bromo-4-oxopyrido[1,2-a]pyrimidin-2-yl)methyl 2,2-dichloro-1-methylcyclopropane-1-carboxylate MLS001017781 AKOS033696592 Z19633138 HMS2631O17 730987-10-7 MolPort-004-028-771 {7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}methyl 2,2-dichloro-1-methylcyclopropane-1-carboxylate MCULE-9322468084 [ Show all ]
Inchi Key	AINAFLGAXJXZDM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H11BrCl2N2O3/c1-13(7-14(13,16)17)12(21)22-6-9-4-11(20)19-5-8(15)2-3-10(19)18-9/h2-5H,6-7H2,1H3
PubChem CID	5186080
ChEMBL	CHEMBL1433143
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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