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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3228809
Molecular formula	C18H27N3O
IUPAC name	1-[2-[di(propan-2-yl)amino]ethyl]-5,7-dimethyl-1,8-naphthyridin-2-one
Molecular weight	301.434
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	BDBM50000411 SCHEMBL11556940
Inchi Key	DMAVWHMFMKGVEG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H27N3O/c1-12(2)20(13(3)4)9-10-21-17(22)8-7-16-14(5)11-15(6)19-18(16)21/h7-8,11-13H,9-10H2,1-6H3
PubChem CID	22753551
ChEMBL	CHEMBL3228809
IUPHAR	N/A
BindingDB	50000411
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ratio	0.011 -	PMID423213	ChEMBL

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