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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL34239
Molecular formula	C20H23N3O
IUPAC name	3-[2-(4-phenylpiperazin-1-yl)ethyl]-2,3-dihydroisoindol-1-one
Molecular weight	321.424
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.8
Synonyms	3-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-2,3-dihydro-isoindol-1-one BDBM50070513 SCHEMBL8174027
Inchi Key	AIKAECUQHAATGN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23N3O/c24-20-18-9-5-4-8-17(18)19(21-20)10-11-22-12-14-23(15-13-22)16-6-2-1-3-7-16/h1-9,19H,10-15H2,(H,21,24)
PubChem CID	9797200
ChEMBL	CHEMBL34239
IUPHAR	N/A
BindingDB	50070513
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	24.5 nM	PMID9873377	ChEMBL
Ki	25.0 nM	PMID9873377	BindingDB

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