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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL15295
Molecular formula	C26H34O7
IUPAC name	2-[3-[3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy]butanoic acid
Molecular weight	458.551
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	6.4
Synonyms	SCHEMBL8583488 2-{3-[3-(4-Acetyl-2-ethyl-5-hydroxy-phenoxy)-propoxy]-2-propyl-phenoxy}-butyric acid BDBM50281876
Inchi Key	DKTWJFBNXZNLCC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H34O7/c1-5-10-19-23(11-8-12-24(19)33-22(7-3)26(29)30)31-13-9-14-32-25-16-21(28)20(17(4)27)15-18(25)6-2/h8,11-12,15-16,22,28H,5-7,9-10,13-14H2,1-4H3,(H,29,30)
PubChem CID	15839733
ChEMBL	CHEMBL15295
IUPHAR	N/A
BindingDB	50281876
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	36.0 nM	, Bioorg. Med. Chem. Lett., (1993) 3:6:1147	BindingDB,ChEMBL
Kb	85.8 nM	Bioorg. Med. Chem. Lett., (1993) 3:6:1147	ChEMBL
Ki	15.5 nM	Bioorg. Med. Chem. Lett., (1993) 3:6:1147	ChEMBL
Ki	16.0 nM	N/A	BindingDB

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