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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL24809
Molecular formula	C22H25N3
IUPAC name	1-benzyl-4-(3-methyl-5-phenylpyrazol-1-yl)piperidine
Molecular weight	331.463
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.3
Synonyms	1-Benzyl-4-(3-methyl-5-phenyl-pyrazol-1-yl)-piperidine 1-Benzyl-4-(3-methyl-5-phenyl-1H-pyrazole-1-yl)piperidine BDBM50077000
Inchi Key	AHVVCJSEQJZGNV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3/c1-18-16-22(20-10-6-3-7-11-20)25(23-18)21-12-14-24(15-13-21)17-19-8-4-2-5-9-19/h2-11,16,21H,12-15,17H2,1H3
PubChem CID	44459452
ChEMBL	CHEMBL24809
IUPHAR	N/A
BindingDB	50077000
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	140.0 nM	PMID10340615	BindingDB,ChEMBL

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