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Name | 5-hydroxytryptamine receptor 1A |
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Species | Rattus norvegicus (Rat) |
Gene | Htr1a |
Synonym | 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 422 |
Amino acid sequence | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR |
UniProt | P19327 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL273 |
IUPHAR | 1 |
DrugBank | N/A |
Name | CHEMBL50722 |
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Molecular formula | C27H38N2O9 |
IUPAC name | 8-[3-[(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-propylamino]propoxy]-8-azaspiro[4.5]decane-7,9-dione;oxalic acid |
Molecular weight | 534.606 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | N/A |
Inchi Key | AHVSCLQWBPQCNA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H36N2O5.C2H2O4/c1-3-12-26(19-15-20-21(30-2)8-6-9-22(20)31-18-19)13-7-14-32-27-23(28)16-25(17-24(27)29)10-4-5-11-25;3-1(4)2(5)6/h6,8-9,19H,3-5,7,10-18H2,1-2H3;(H,3,4)(H,5,6) |
PubChem CID | 44295541 |
ChEMBL | CHEMBL50722 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.0 nM | PMID7912735 | ChEMBL |
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