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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2089223
Molecular formula	C15H9F2NO4
IUPAC name	3-(3,5-difluorophenyl)-5,6-dihydroxy-1H-indole-2-carboxylic acid
Molecular weight	305.237
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	3.0
Synonyms	BDBM50420393 SCHEMBL14702792
Inchi Key	DFOHFXJPRRQDAG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H9F2NO4/c16-7-1-6(2-8(17)3-7)13-9-4-11(19)12(20)5-10(9)18-14(13)15(21)22/h1-5,18-20H,(H,21,22)
PubChem CID	70687104
ChEMBL	CHEMBL2089223
IUPHAR	N/A
BindingDB	50420393
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4360.0 nM	PMID24900508	BindingDB,ChEMBL
EC50	109000.0 nM	PMID24900508	BindingDB,ChEMBL
Efficacy	48.0 %	PMID24900508	ChEMBL

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