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Name | Kappa-type opioid receptor |
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Species | Mus musculus (Mouse) |
Gene | Oprk1 |
Synonym | MSL-1 KOR-1 KOPr KOP Kappa receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 380 |
Amino acid sequence | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV |
UniProt | P33534 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4329 |
IUPHAR | 318 |
DrugBank | N/A |
Name | CHEMBL2164300 |
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Molecular formula | C26H36N2O4 |
IUPAC name | N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]heptanamide |
Molecular weight | 440.584 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 2.0 |
Synonyms | BDBM50395101 |
Inchi Key | DEIYKJORPVFGSX-HFXSLSFNSA-N |
Inchi ID | InChI=1S/C26H36N2O4/c1-3-5-6-7-8-21(30)27-18-11-12-26(31)20-16-17-9-10-19(29)23-22(17)25(26,24(18)32-23)13-15-28(20)14-4-2/h4,9-10,18,20,24,29,31H,2-3,5-8,11-16H2,1H3,(H,27,30)/t18-,20-,24+,25+,26-/m1/s1 |
PubChem CID | 60195722 |
ChEMBL | CHEMBL2164300 |
IUPHAR | N/A |
BindingDB | 50395101 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 9.15 nM | PMID22734622 | BindingDB,ChEMBL |
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