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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3641732
Molecular formulaC16H20N4O
IUPAC name4,6-dimethyl-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight284.363
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.9
SynonymsUS8802673, 182
BDBM129540
SCHEMBL12610067
Inchi KeyDEIBCWTWDNPRAD-HNNXBMFYSA-N
Inchi IDInChI=1S/C16H20N4O/c1-11-9-12(2)19-16(18-11)20-14-5-3-13(4-6-14)15-10-17-7-8-21-15/h3-6,9,15,17H,7-8,10H2,1-2H3,(H,18,19,20)/t15-/m0/s1
PubChem CID68325754
ChEMBLCHEMBL3641732
IUPHARN/A
BindingDB129540
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki14.4 nM, NoneBindingDB,ChEMBL

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