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GLASS

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GPCR

Name	Metabotropic glutamate receptor 7
Species	Homo sapiens (Human)
Gene	GRM7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A
Length	915
Amino acid sequence	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	Q14831
Protein Data Bank	5c5c, 3mq4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5c5c.
BioLiP	BL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3777
IUPHAR	295
DrugBank	BE0000834

Ligand

Name	2-amino-4-phosphonobutanoic acid
Molecular formula	C4H10NO5P
IUPAC name	2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	BDBM50004051 DL-2-Amino-4-phosphonobutyric acid IN1534 L-2-amino-4-phosphonobutyrate NCGC00015041-03 NCI60_002523 ( inverted question mark)-2-Amino-4-phosphonobutyric acid PDSP2_000805 Butanoic acid, 2-amino-4-phosphono- D00IGI FCH1114914 L -(+)-2-Amino-4-phosphono- butanoic acid Lopac0_000064 NCGC00015041-06 NSC-354086 (+/-)-2-Amino-4-phosphonobutyric acid SR-01000075414-1 2-Amino-4-phosphono-butyric acid (AP4) AC1L1D5X C-51648 DL-2-Amino-4-phosphono-butanoic acid HMS3260M09 L-2-amino-4-phosphobutyric acid MFCD00013999 NCGC00024466-04 OR311226 (?)-2-Amino-4-phosphonobutyric acid 20263-07-4 AKOS015892998 BN0082 CHEMBL285843 DL-AP4 J-013164 L-AP4 cpd, butyric NCGC00015041-04 NSC 30079 ( inverted question mark)-AP-4 SCHEMBL56139 2 APB 6323-99-5 Butanoic acid, 2-amino-4-phosphono- (9CI) DDOQBQRIEWHWBT-UHFFFAOYSA-N FT-0625388 L -AP4 LP00064 NCGC00024466-02 NSC30079 (+/-)-2-Amino-4-phosphonobutyric acid, solid SR-01000075414-3 AC1Q6RPJ CCG-204159 DL-2-Amino-4-phosphonobutanoic acid (AP4) I04-1589 L-2-amino-4-phosphonobutanoic acid MolPort-002-513-394 NCGC00260749-01 ( inverted exclamation markA)-AP-4 PDSP1_000818 (y)-2-Amino-4-phosphonobutyric acid 4-Amino Phosphonobutyrate AM807295 BRN 5255932 CTK5B8255 EU-0100064 KS-000024GC L000344 NCGC00015041-05 NSC-30079 (+/-)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID SR-01000075414 2-Amino-4-phosphono-butyric acid Abu(P) BUTYRIC ACID, 2-AMINO-4-PHOSPHONO- DL-0710 GlcN-6-P synthase inhibitor, 1 (racemic mixture) L-(+)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID LS-47843 NCGC00024466-03 NSC354086 (+/-)-AP-4 Tox21_500064 2-Amino-4-phosphonobutyric acid ACM20263074 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
PubChem CID	2207
ChEMBL	CHEMBL285843
IUPHAR	N/A
BindingDB	50004051
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9131252	PDSP,BindingDB

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