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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Iodoproxyfan
Molecular formula	C13H15IN2O
IUPAC name	5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole
Molecular weight	342.18
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	CHEMBL19010 SCHEMBL3089477 5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole GTPL1253 BDBM22916 PDSP1_000544 152028-96-1 D08BSG ZINC5117186 3-(1H-Imidazol-4-yl)propyl-(4-iodophenyl)methyl ether 5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole (125I)Iodoproxyfan PDSP2_000542 1H-Imidazole, 4-(3-((4-iodophenyl)methoxy)propyl)- DTXSID30164942 4-[3-[(4-iodophenyl)methoxy]propyl]-3H-imidazole AC1L31V0 L010934 [ Show all ]
Inchi Key	DCQNAFOCXVCDLB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
PubChem CID	132937
ChEMBL	CHEMBL19010
IUPHAR	1253
BindingDB	22916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
-Log KB	5.8 -	PMID8632428	ChEMBL

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