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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Cannabinoid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Cnr2
Synonym	Peripheral cannabinoid receptor CB2-R CB2 receptor CB2 CB-2 cannabinoid receptor 2 (spleen) cannabinoid receptor 2 (macrophage) rCB2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProt	Q9QZN9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2470
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1-Arachidonoyl-sn-glycerol
Molecular formula	C23H38O4
IUPAC name	[(2S)-2,3-dihydroxypropyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Molecular weight	378.553
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.5
Synonyms	CHEBI:34071 MG(20:4w6/0:0) 1-arachidonoyl-glycerol 1AG Glyceryl 1-arachidonate, (S)- UNII-6UXX4LRJ92 component DCPCOKIYJYGMDN-HUDVFFLJSA-N (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate MG(20:4(5Z,8Z,11Z,14Z)/0:0/0:0) ZINC4654971 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol P471A4329T 5,8,11,14-Eicosatetraenoic acid, (2S)-2,3-dihydroxypropyl ester, (5ZZ,8Z,11Z,14Z)- MAG(20:4n6/0:0) UNII-I4WS2B978B component DCPCOKIYJYGMDN-HUDVFFLJSA-N (S)-glyceryl 1-arachidonate BDBM50117249 MG(20:4n6/0:0) 1-AG 124511-15-5 CHEMBL124426 SCHEMBL4064708 5,8,11,14-Eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (S-(all-Z))- MAG(20:4w6/0:0) UNII-P471A4329T 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-rac-glycerol [ Show all ]
Inchi Key	DCPCOKIYJYGMDN-HUDVFFLJSA-N
Inchi ID	InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-21-22(25)20-24/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-/t22-/m0/s1
PubChem CID	16019980
ChEMBL	CHEMBL124426
IUPHAR	N/A
BindingDB	50117249
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<1000.0 nM	PMID12166944	BindingDB,ChEMBL

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