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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL294394
Molecular formula	C15H19N3
IUPAC name	1-phenyl-4-(1H-pyrrol-2-ylmethyl)piperazine
Molecular weight	241.338
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.2
Synonyms	Piperazine, 1-phenyl-4-(1H-pyrrol-2-ylmethyl)- 245663-89-2 DTXSID70514604 1-Phenyl-4-[(1H-pyrrol-2-yl)methyl]piperazine ZINC13443853 1-Phenyl-4-(1H-pyrrol-2-ylmethyl)-piperazine KB-219694 2-(4-Phenylpiperazinomethyl)-1H-pyrrole BDBM50115719 CTK0J4786 1-phenyl-4-(1h-pyrrol-2-ylmethyl)piperazine [ Show all ]
Inchi Key	DCDSVYQQSBWIRG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H19N3/c1-2-6-15(7-3-1)18-11-9-17(10-12-18)13-14-5-4-8-16-14/h1-8,16H,9-13H2
PubChem CID	12997400
ChEMBL	CHEMBL294394
IUPHAR	N/A
BindingDB	50115719
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	570.0 nM	PMID12113813	BindingDB,ChEMBL

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