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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	D-Luciferin
Molecular formula	C11H8N2O3S2
IUPAC name	(4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
Molecular weight	280.316
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.2
Synonyms	SCHEMBL565455 (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid ZINC20230681 (S)-4,5-Dihydro-2-(6-hydroxybenzothiazol-2-yl)thiazole-4-carboxylic acid 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (S)- AJ-43365 C-48220 d(-)-2-(6'-hydroxy-benzothiazolyl)-delta2-thiazoline-4-carboxylic acid D-Luciferin potassium salt FT-0625527 Luciferin MolPort-002-045-691 TD8085 (4S)-2-(6-oxo-1,3-benzothiazol-2-ylidene)-1,3-thiazolidine-4-carboxylic acid ZX-AFC000225 4,5-dihydro-(6-hydroxy-2-benzothiazoyl)-4-thiazole carboxylic acid 5TBB02N29K AN-7927 CHEBI:17165 D-(-)-Luciferin D-Luciferin, synthetic, BioXtra, >=99% (HPLC) I14-53997 s7763 (2Z,4S)-2-(6-oxo-1,3-benzothiazol-2-ylidene)-1,3-thiazolidine-4-carboxylic acid Z5789 (S)-4,5-Dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)thiazole-4-carboxylic acid 4,5-dihydro-2-[6-hydroxy-2-benzothiazolyl]-4-thiazole-carboxylic acid AC1NUSHR BDBM50440036 CS-4970 D-Luciferin Free Acid EX-A617 KS-00000G3T Luciferin (firefly) ST24035888 (4S)-2-(6-Hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid ZINC255979881 (S,Z)-2-(6-oxobenzo[d]thiazol-2(6H)-ylidene)thiazolidine-4-carboxylic acid 4-Thiazolecarboxylicacid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)- AK-78636 C02740 D(-)-LUCIFERIN D-Luciferin, Potassium Salt FT-0642802 Photinus luciferin TR-011751 (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxy AC-8545 ANW-43638 EINECS 219-981-3 IWJYWBVPCGUPLO-BFUDMSGGSA-N SCHEMBL49401 (2Z,4S)-2-(6-oxo-1,3-benzothiazol-2-ylidene)thiazolidine-4-carboxylic acid ZINC20230679 (S)-4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)- AC1ODYZG BJGNCJDXODQBOB-SSDOTTSWSA-N CTK1A2267 D-Luciferin free acid, 99% Firefly luciferin L-8200 Luciferin, D- ST50405784 (4S)-2-(6-hydroxybenzothiazol-2-yl)-1,3-thiazoline-4-carboxylic acid ZINC2584195 2591-17-5 AKOS015916008 C11H8N2O3S2 D(-)-Luciferin, D(-)-2-(6'-Hydroxy-benzothiazolyl)D2-thiazoline-4-carboxylic acid from Photinus pyralis, synthetic D-Luciferin, synthetic HY-12591A RTR-011751 (2E,4S)-2-(6-oxo-1,3-benzothiazol-2-ylidene)-1,3-thiazolidine-4-carboxylic acid UNII-5TBB02N29K (S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid AC1NUNCB AS-54711 CHEMBL443738 D-Luciferin Firefly EN300-99574 KB-03723 [ Show all ]
Inchi Key	BJGNCJDXODQBOB-SSDOTTSWSA-N
Inchi ID	InChI=1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
PubChem CID	92934
ChEMBL	CHEMBL443738
IUPHAR	N/A
BindingDB	50440036
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	11.0 %	PMID23888932	ChEMBL
EC50	12900.0 nM	PMID23888932	BindingDB,ChEMBL
EC50	277000.0 nM	PMID23888932	BindingDB,ChEMBL
Ki	9860.0 nM	PMID23888932	BindingDB,ChEMBL

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