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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	SCHEMBL15578761
Molecular formula	C21H22N6O2
IUPAC name	1-(6-cyclopropylpyrimidin-4-yl)-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrazole-4-carboxamide
Molecular weight	390.447
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.9
Synonyms	US9487501, 56 BDBM256455
Inchi Key	AVLAZSACGWVQTL-LJQANCHMSA-N
Inchi ID	InChI=1S/C21H22N6O2/c28-21(26-17-5-3-15(4-6-17)19-11-22-7-8-29-19)16-10-25-27(12-16)20-9-18(14-1-2-14)23-13-24-20/h3-6,9-10,12-14,19,22H,1-2,7-8,11H2,(H,26,28)/t19-/m1/s1
PubChem CID	73442505
ChEMBL	N/A
IUPHAR	N/A
BindingDB	256455
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.2 nM	N/A	BindingDB

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