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Name | Kappa-type opioid receptor |
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Species | Mus musculus (Mouse) |
Gene | Oprk1 |
Synonym | MSL-1 KOR-1 KOPr KOP Kappa receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 380 |
Amino acid sequence | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV |
UniProt | P33534 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4329 |
IUPHAR | 318 |
DrugBank | N/A |
Name | SCHEMBL11932315 |
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Molecular formula | C38H55N9O6 |
IUPAC name | (2S)-1-[1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(diaminomethylideneamino)propanoyl]piperidin-4-yl]pyrrolidine-2-carboxylic acid |
Molecular weight | 733.915 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 7 |
XlogP | -0.5 |
Synonyms | US9359399, 14 BDBM235801 |
Inchi Key | ACSLJSZFBBPSQA-ROQXEPJXSA-N |
Inchi ID | InChI=1S/C38H55N9O6/c1-24(2)20-29(44-35(50)30(22-26-12-7-4-8-13-26)43-33(48)28(39)21-25-10-5-3-6-11-25)34(49)45-31(23-42-38(40)41)36(51)46-18-15-27(16-19-46)47-17-9-14-32(47)37(52)53/h3-8,10-13,24,27-32H,9,14-23,39H2,1-2H3,(H,43,48)(H,44,50)(H,45,49)(H,52,53)(H4,40,41,42)/t28-,29-,30-,31-,32+/m1/s1 |
PubChem CID | 53380717 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 235801 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.349 nM | N/A | BindingDB |
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