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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Mus musculus (Mouse)
Gene	Htr2b
Synonym	5-HT-2B serotonin receptor 2B NP75 protein 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F stomach fundus serotonin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
UniProt	Q02152
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2583
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	2-Methyl-5-hydroxytryptamine
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	1.4
Synonyms	2-Me 5-HT 3-(2-Aminoethyl)-5-hydroxy-2-methylindole AKOS016362704 Lopac0_000813 NCGC00024652-01 ZINC2572146 2-Methyl-5-HT 78263-90-8 BPBio1_001361 DTXSID80228927 NCGC00015628-01 NS-01775 AC1Q2F2H CCG-204897 L000061 NCGC00015628-04 SCHEMBL399028 1H-Indol-5-ol, 3-(2-aminoethyl)-2-methyl- 2-Me-5-HT 5-HT,2-Me BDBM50014406 CHEMBL266591 LS-83657 NCGC00024652-02 AC-30467 BRD-K64137799-003-01-7 GTPL218 NCGC00015628-02 PDSP1_001520 3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol AJ-41965 CHEBI:31085 Lopac-M-109 NCGC00015628-05 Tocris-0558 1H-Indol-5-ol,3-(2-aminoethyl)-2-methyl- 2-Me-5HT Biomol-NT_000098 D00CRA MolPort-020-248-203 NCGC00024652-03 2-Methylserotonin AC1L1BRL C13665 KB-231570 NCGC00015628-03 PDSP2_001504 [ Show all ]
Inchi Key	WYWNEDARFVJQSG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
PubChem CID	1574
ChEMBL	CHEMBL266591
IUPHAR	218
BindingDB	50014406
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6606.93 nM	PMID7984267	BindingDB

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