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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	Vanoxerine
Molecular formula	C28H32F2N2O
IUPAC name	1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
Molecular weight	450.574
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.6
Synonyms	Prestwick2_000386 Vanoxeamine 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine AKOS003588978 BPBio1_001141 CHEBI:64089 DTXSID8045143 Lopac0_000446 NCGC00015300-08 SCHEMBL246574 4145AH BCP21322 BRD-K32501161-300-04-7 CS-2714 GBR12909 NCGC00015300-01 NCGC00024581-03 Prestwick0_000386 Tocris-0421 Vanoxerinum [INN-Latin] 1-(2-BIS -[4-FLUOROPHENYL]- METHOXYETHYL)-4-(3-PHENYL- 2-PROPYL)PIPERAZINE AB00053750 Biomol-NT_000010 CAS-67469-78-7 DB03701 KBio1_001940 NCGC00015300-04 Prestwick3_000386 Vanoxerina 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine API0015860 BRD-K32501161-001-01-7 Gbr 12909 LS-187205 NCGC00024581-01 NCI60_038175 SPBio_002492 Vanoxerine [INN] 67469-69-6 BCPP000022 BSPBio_000571 D-052 GTPL9983 NCGC00015300-02 Prestwick1_000386 UNII-90X28IKH43 ZINC22034135 1-(2-bis-[4-FLUOROPHENYL]-METHOXYETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE AC1L1FZ5 BPBio1_000629 CCG-204538 DivK1c_006996 Lopac-D-052 NCGC00015300-07 SB16842 Vanoxerina [INN-Spanish] API0024562 BRD-K32501161-300-03-9 CHEMBL281594 GBR-12909 NAUWTFJOPJWYOT-UHFFFAOYSA-N NCGC00024581-02 Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)- SpecPlus_000900 Vanoxerinum 1-(2-(Bis(p-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine 90X28IKH43 BDBM22165 C28H32F2N2O D0N2HF HY-13217A NCGC00015300-03 [ Show all ]
Inchi Key	NAUWTFJOPJWYOT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2
PubChem CID	3455
ChEMBL	CHEMBL281594
IUPHAR	N/A
BindingDB	22165
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	109.0 nM	PMID9686407	BindingDB

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