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GLASS

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GPCR

Name	Nociceptin receptor
Species	Mus musculus (Mouse)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 ORGC Orphanin FQ receptor NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor K3 opiate receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35377
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621
IUPHAR	320
DrugBank	N/A

Ligand

Name	DQCKKXVULJGBQN-UHFFFAOYSA-N
Molecular formula	C20H23NO4
IUPAC name	3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight	341.407
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.9
Synonyms	AC1L1I5A EN 1939 NSC_27943 CAS_27943 Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-.alpha.-epoxy-3,14-dihydroxy- Trexan (Salt/Mix) 17-(Cyclopropylmethyl)-4,5.alpha.-epoxy-3,14-dihydroxymorphinan-6-one Naltrexone hydrochloride (Salt/Mix) BDBM86493 L000663 SCHEMBL10031254 CHEBI:91912 Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5.alpha.)- VA11979 EN 1639 NALTREXONE-HCl BRD-A83855350-003-01-4 MCULE-4222870229 STL452820 17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one CHEMBL36504 Naltrexone base anhydrous [ Show all ]
Inchi Key	DQCKKXVULJGBQN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2
PubChem CID	4428
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86493
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1000.0 nM	PMID11546835	BindingDB

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