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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	NINDS_000278 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Oprea1_602476 EINECS 239-753-7 (y)-Sulpiride PubChem17241 FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide S 8010 HMS3371P16 Aiglonyl SR-01000075402 IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- Sulpirida L000579 BPBio1_000233 Sulpiride, SLP Lopac0_001050 C15H23N3O4S Sulpride MFCD00055061 Z84655412 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide NCGC00015966-08 DB00391 Nufarol DSSTox_GSID_42574 (?)-Sulpiride Prestwick1_000056 EU-0001755 R. D. 1403 HMS1568K13 676S161 SCHEMBL8421 HMS3651G12 AN-1017 SR-01000075402-6 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Sulpiride (JP17/USAN/INN) Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 Sulpiride-R LS-20059 CCG-205127 Sursumid Misulvan NCGC00015966-03 CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide NCGC00024852-04 dl-sulpiride ( inverted question mark)-Sulpiride (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Omiryl Eglonil (RS)-(+/-)-sulpiride Prestwick_431 Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide Restful HMS3263A22 AC-12181 SPBio_002132 HY-B1019 BCP13871 Sulperide Kylistro Biomol-NT_000037 Sulpiride, British Pharmacopoeia (BP) Reference Standard Levosulpiridum [INN-Latin] BRN 0494008 Sulpitil MCULE-7506797476 Championyl Tox21_501050 MolPort-002-070-475 NCGC00015966-06 Darleton NCGC00261735-01 Dogmatyl Norestran Dresent (+/-)-Sulpiride Ozoderpin Enimon Pyrikappl GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) S0501 HMS3372O01 AKOS004912732 SR-01000075402-2 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Sulpirida [INN-Spanish] Levopraid BPBio1_000463 SULPIRIDE,(+) LP01050 Calmoflorine Sulpyrid Miradol CHEMBL26 Zemorcon N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide NCGC00024852-02 Desmenat (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- DSSTox_RID_80050 (plusmn)-sulpiride Prestwick2_000056 EU-0101050 15676-16-1 R.D. 1403 HMS2095K13 AB0105833 Sernevin HMS3712K13 AN-1019 Stamonevrol KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Sulpiride 1.0 mg/ml in Methanol Levosulpiride [INN] BRD-A55272860-001-04-7 Sulpiridum Magnetic resonance imaging sulpiride CCRIS 4248 Synedil MLS000069434 NCGC00015966-04 CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide NCGC00024852-05 Dobren (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Omperan Eglonyl (RS)-(A+/-)-Sulpiride Psicocen Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide RV-12309 HMS3266P12 AC1L1K62 Splotin I06-0054 BDBM11638 Sulpirid L-Sulpiride Biomol-NT_000162 Sulpiride, European Pharmacopoeia (EP) Reference Standard Lisopiride BSPBio_000211 Sulpor Meresa CHEBI:32168 Valirem N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide NCGC00015966-07 Neogama Dogmatyl (TN) Normum DSSTox_CID_22574 (.+/-.)-Sulpiride Prestwick0_000056 Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Pyrkappl Guastil s4655 HMS3393A08 Alimoral SR-01000075402-3 J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida BPBio1_001255 SULPIRIDE,(-) LS-20058 CAS-15676-16-1 Suprium Mirbanil N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide NCGC00024852-03 DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide (+-)-sulpiride o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Prestwick3_000056 Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide RD 1403 HMS2231K07 Abilit SMR000038923 HMS500N20 BCP04500 STK368596 KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N Sulpiride [USAN:INN:BAN:JAN] Levosulpiridum BRD-A55272860-001-08-8 Sulpiridum [INN-Latin] Mariastel CCRIS-4248 Tox21_302205 MLS001306443 NCGC00015966-05 D01226 NCGC00255813-01 Dogmatil [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2869639	BindingDB

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