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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	ADTN
Molecular formula	C10H13NO2
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.4
Synonyms	Lopac0_000415 NCGC00162147-01 SCHEMBL3126243 53463-78-8 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide Biomol-NT_000003 cMAP_000069 KB-199024 KBio2_007647 NCGC00015291-02 NCGC00162147-04 SR-01000075362-6 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene 6,7-Dihydroxy-3-chromanamine AC1L1FAH CCG-204507 FT-0645288 KBioSS_002519 NCGC00015291-05 PDSP2_000476 (+)-ADTN 2-aminotetralin-6,7-diol;hydrobromide 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol AKOS006328808 cid_11957526 HMS1990C05 KBio2_002511 LS-175452 NCGC00162147-02 SMR001254097 2,3-Naphthalenediol, 6-amino-5,6,7,8-tetrahydro- 6,7-Adtn BPBio1_001127 CTK4J8115 KBio3_002989 NCGC00015291-03 PDSP1_000478 2-Amino-6,7-dihydroxytetralin 6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediol AC1Q79PY GTPL932 L000081 NCGC00015291-06 PDSP2_000807 (+)-ADTN (aminotetralin-6,7-diol) 463A788 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide BDBM81195 cid_3153 HMS3403C05 KBio2_005079 MLS002172466 NCGC00162147-03 SR-01000075362 2,3-Naphthalenediol,6-amino-5,6,7,8-tetrahydro- 6,7-Dihydroxy-2-aminotetralin BSPBio_001023 D0X2NO KBioGR_002511 NCGC00015291-04 PDSP1_000820 2-aminotetralin-6,7-diol 6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol CHEMBL26736 HMS1792C05 [ Show all ]
Inchi Key	ASXGAOFCKGHGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
PubChem CID	3153
ChEMBL	CHEMBL26736
IUPHAR	932
BindingDB	81195
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	393.0 nM	PMID8097160	BindingDB

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