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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Ortopsique Apo-diazepam Zepaxid GTPL3364 Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Paxum Baogin I06-0194 SCHEMBL21442 Diazepam [USAN:USP:INN:BAN:JAN] Pro pam Betapam KBioGR_001012 Servizepam Quievita C-17931 Lamra 11100-37-1 Solis Ro-52807 Caudel Mandro-Zep 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one T-quil Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Tranqdyn Dipezona D07JVL NCGC00178168-01 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Unisedil DSSTox_GSID_20406 Dialag neurolytr il AC1L1EZE Valium R e-Pam Diastat Acudial Novo-Dipam Anlin Vival Faustan Diazepam (intranasal, epilepsy) Frustan Diazepam 1.0 mg/ml in Methanol Paralium Arzepam HMS3393N04 S.A. R.L Diazepam Rectubes Placidox 5 BCP9000199 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Seduksen Diazepam-Eurogenerics Q-pam BIDD:PXR0158 Kratium 2 Sibazone Relanium Calmocitene Liberetas Spectrum4_000576 CCRIS 6009 Medipam 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Tox21_113071 Diazepin Condition MLS000759402 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Tranquo-puren Dizac DEA No. 2765 NCGC00178168-04 A3662/0155188 Valeo Ducene Diapax Nivalen Aliseum Vanconin Eridan Diazapam NSC-169897 Ansiolisina Winii NSC77518 Anxionil WY-3467 Gihitan Diazepam Elmu Paxate Atilen HSDB 3057 SAM001246536 Diazepam Stada Pms-Diazepam Benzopin KBio1_000967 Serenamin Diazepamu Quetinil BRN 0754371 LA-111 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Sipam Ro 5-2805 Calmpose LS-122 Stesolin Ceregulart Methyl diazepinone 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Tranimul Dipam D-Pam Morosan 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Umbrium Drenian Diacepan Nerozen AB02310 Valium Duxen Diastat Notense AN-23449 Vazepam Evacalm Diazemulus Diazepam (JP17/USP/INN) Paceum Apozepam ZINC6427 Gubex Diazepam Intensol Placidox 10 BCP0726000176 Iazepam Sedapam Diazepam, European Pharmacopoeia (EP) Reference Standard Prozepam Bialzepam Kiatrium Setonil Radizepam C06948 Lembrol 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Sonacon Ruhsitus CC-26451 Mandrozep 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Tensium Diazepan CHEMBL12 Methyldiazepinone, pharmaceutical 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Tranquase Disopam D0Y1YC NCGC00178168-02 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Usempax ap DSSTox_RID_75566 Dialar Neurolytril AKOS003367969 Valrelease EINECS 207-122-5 Diastat, Valium Novodipam Ansilive Vivol Faustan, FT-0632135 Diazepam Dak Paranten Assival HMS503A15 S.a. r.l. Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Plidan BDBM50000766 Jinpanfan Seduxen Diazepam-Lipuro Q-Pam Relanium BRD-K16508793-001-01-8 LA 111 Sico Relax Reliver Calmociteno Lizan 439-14-5 Spectrum5_001890 Centrazepam Mentalium 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Tox21_113071_1 Diazetard CPD000058398 MLS001424086 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Tranquo-tablinen Domalium Desconet NCGC00260007-01 A826456 Valiquid Duksen Diapine Nixtensyn Alupram Vatran Euphorin P Diazem NSC-77518 Antenex WLN: T67 GNV JN IHJ CG G1 KR Oprea1_126223 Apaurin ZB000640 Gradual Diazepam Fabra Paxel Azedipamin HY-17027 Saromet Diazepam [USAN:INN:BAN:JAN] Pomin Best [Pharaceutical] KBio3_002780 Serenzin Diazepamu [Polish] Quiatril BSPBio_003279 La-Iii 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one SMR000058398 Ro 5-2807 CAS-439-14-5 Mandro 53320-84-6 STK735517 Diazepamum CHEBI:49575 Methyldiazepinone 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Trankinon Dipaz D00293 NC00247 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one UNII-Q3JTX2Q7TU DSSTox_CID_406 Diaceplex Nervium AC-10561 Valium (TN) DZP Diastat (TN) Novazam An-Ding Velium Faustal Diazepam 0.1 mg/ml in Methanol Pacitran Armonil Zipan HMS2051N04 Diazepam Nordic Placidox 2 BCP23002 IDI1_000967 Sedipam Diazepam, United States Pharmacopeia (USP) Reference Standard Psychopax BIDD:GT0105 Kratium Sibazon Relaminal Calmaven Levium 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Spectrum3_001780 CCG-100997 MCULE-8990989144 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Tensopam Diazepan leo Chuansuan Metil Gobanal 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Tranquirit DivK1c_000967 DB00829 NCGC00178168-03 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Valaxona DTXSID4020406 Diapam NINDS_000967 Alboral Valuzepam Elcion CR Diatran NSC 169897 Ansiolin W-5055 Freudal Anxicalm Wy 3467 Gewacalm Diazepam Desitin Parzam Atensine Horizon S.A.R.L. Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Plumiaz Bensedin Kabivitrum Serenack Diazepam-ratiopharm Q3JTX2Q7TU Britazepam LA III (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Simasedan Renborin Calmod Lovium 5-24-04-00300 (Beilstein Handbook Reference) Stesolid Cercine Metamidol 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Tox21_202458 Dienpax CS-0653 Mono (2-ethylhexyl) phthalate 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Trazepam Doval Desloneg Nellium AAOVKJBEBIDNHE-UHFFFAOYSA-N Valitran Dupin Diaquel Noan Amiprol Vazen Eurosan Diazemuls NSC169897 [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6387355	BindingDB

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