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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 14
Species	Rattus norvegicus (Rat)
Gene	P2ry14
Synonym	UDP-glucose receptor purinergic receptor P2Y P2Y14 receptor P2Y14 P2Y purinoceptor 14 GPR105 G-protein coupled receptor 105 G protein-coupled receptor 105 G protein coupled receptor for UDP-glucose VTR 15-20 [ Show all ]
Disease	N/A for non-human GPCRs
Length	305
Amino acid sequence	MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS
UniProt	O35881
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	330
DrugBank	N/A

Ligand

Name	Uridine 5'-diphosphate
Molecular formula	C9H14N2O12P2
IUPAC name	[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight	404.161
Hydrogen bond acceptor	12
Hydrogen bond donor	6
XlogP	-4.7
Synonyms	DB-053298 NCGC00163324-01 Uridine 5'-(trihydrogen pyrophosphate) Uridine Pyrophosphate XCCTYIAWTASOJW-XVFCMESISA-N 58-98-0 bmse000266 CHEBI:17659 FT-0601269 UNII-5G0F599A1Y Uridine 5'-pyrophosphate uridine-5'-diphosphate [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate 1o7o AC1Q1I4G CTK1G9536 Lopac0_001205 Uridine 5'-(trihydrogen diphosphate) (9CI) URIDINE DIPHOSPHATE URIDINE_DIPHOSPHATE BDBM50118239 DB03435 SCHEMBL4245 Uridine 5'-(trihydrogen pyrophosphate) (8CI) Uridine pyrophosphate (7CI) ZINC4490939 1gww 5G0F599A1Y C00015 FT-0615129 uridine 5''-(trihydrogen diphosphate) Uridine 5'-pyrophosphorate uridine-5-pyrophosphoric acid [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid 2,4(1H,3H)-pyrimidinedione, 1-[5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-D-ribofuranosyl]- AKOS028109013 D02HAL LS-160842 Uridine 5'-(trihydrogen diphosphate-P-32P) (9CI) Uridine diphosphate (6CI) V1660 ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate BDBM50403871 EINECS 200-409-6 UDP Uridine, 5'-(trihydrogen diphosphate) [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate 1gx4 AC1L1LNF C9H14N2O12P2 CHEMBL130266 GTPL1749 Uridine 5'-(trihydrogen diphosphate) Uridine 5'-pyrophosphoric acid uridine-diphosphate 5'-UDP AN-41775 [ Show all ]
Inchi Key	XCCTYIAWTASOJW-XVFCMESISA-N
Inchi ID	InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6031
ChEMBL	CHEMBL130266
IUPHAR	1749
BindingDB	50118239, 50403871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
IC50	316.228 nM	PMID18252808	IUPHAR

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