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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin D2 receptor 2
Species	Mus musculus (Mouse)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProt	Q9Z2J6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2291
IUPHAR	339
DrugBank	N/A

Ligand

Name	15deoxy-delta-12,14-PGJ2
Molecular formula	C20H28O3
IUPAC name	(Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
Molecular weight	316.441
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.0
Synonyms	1233AH D01RQK NSC-720093 (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid AC1NR1DM ZINC4655372 15d-Delta12,14-PGJ2 GTPL1877 87893-55-8 NSC720093 11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC ACID CHEMBL520218 LS-125843 (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid 89886-60-2 SCHEMBL1440733 [ Show all ]
Inchi Key	VHRUMKCAEVRUBK-WKELIDJCSA-N
Inchi ID	InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6-,18-13+/t17-/m0/s1
PubChem CID	5283035
ChEMBL	N/A
IUPHAR	1877
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	25.1189 nM	PMID12721327	IUPHAR

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