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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin D2 receptor 2
Species	Mus musculus (Mouse)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProt	Q9Z2J6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2291
IUPHAR	339
DrugBank	N/A

Ligand

Name	prostaglandin J2
Molecular formula	C20H30O4
IUPAC name	(Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
Molecular weight	334.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.6
Synonyms	UQOQENZZLBSFKO-POPPZSFYSA-N 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoate 9-Deoxy-delta-9-prostaglandin D2 CHEMBL1397260 HMS3648L18 PGJ2 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid-cyclo[8S,12R] BML1-G07 GTPL1885 LS-176073 SCHEMBL5700581 SR-05000002330-2 (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-cyclopent-2-en-1-yl]hept-5-enoic acid 8-epi-15-J2t-IsoP C05957 HMS1989K20 NCGC00161294-02 ZINC12496015 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoic acid AC1NQXQ1 D0Y6OX IDI1_033968 Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)- SMP2_000100 (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid BRD-K56811497-001-03-2 HMS1361K20 MolPort-003-959-398 SR-05000002330-3 (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid 9-Deoxy-delta-9-pgd2 CHEBI:27485 HMS3402K20 NCGC00161294-03 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid AKOS024418774 DTXSID4041105 LMFA03010019 SR-05000002330 (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid 60203-57-8 BSPBio_001498 HMS1791K20 NCGC00161294-01 [ Show all ]
Inchi Key	UQOQENZZLBSFKO-POPPZSFYSA-N
Inchi ID	InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1
PubChem CID	5280884
ChEMBL	N/A
IUPHAR	1885
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	50.1187 nM	PMID12721327	IUPHAR

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