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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin D2 receptor 2
Species	Mus musculus (Mouse)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProt	Q9Z2J6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2291
IUPHAR	339
DrugBank	N/A

Ligand

Name	delta(12)-PGJ2
Molecular formula	C20H30O4
IUPAC name	(Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
Molecular weight	334.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.9
Synonyms	NCGC00161301-02 11-oxo-15S-hydroxy-5Z,9Z,13E-prostatrienoic acid 9-Deoxy-delta-9,12-pgd2 CHEMBL519797 Delta-12 PGJ-2 HMS1791A06 Prosta-5,9,12-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12E,15S)- BML2-B02 D12-prostaglandin J2 delta-12-Prostaglandin J2 IDI1_033754 SR-01000946874-1 (Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid 9-Deoxy-delta(9), delta(12)-13,14-dihydroprostaglandin D2 C05958 GTPL1876 MolPort-027-640-982 NCGC00161301-03 13,14-dihydro-Delta(12)-prostaglandin J2 9-Deoxy-delta-9,12-prostaglandin D2 D0MS3D delta-12-PGJ2 HMS1989A06 SCHEMBL3368873 (5Z,12E,15S)-15-hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid 87893-54-7 BRD-K83820346-001-02-5 Dddd-PGD2 Delta12-PGJ2 LMFA03010020 NCGC00161301-01 ZINC4096983 102839-03-2 9-Deoxy-delta(9,12)-13,14-dihydro PGD2 CHEBI:28130 delta(12)-Prostaglandin J2 HMS1361A06 Prosta-5,9,12,13-tetraen-1-oic acid, 15-hydroxy-11-oxo-, (5Z,15S)- 1703AH AC1NQXQ4 d12-PGJ2 delta-12-Prostaglandin D2 HMS3402A06 SR-01000946874 (Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid 9-Deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 BSPBio_001284 delta(12)-Pgj(2) delta12-PROSTAGLANDIN J2 LS-178022 [ Show all ]
Inchi Key	TUXFWOHFPFBNEJ-GJGHEGAFSA-N
Inchi ID	InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1
PubChem CID	5280885
ChEMBL	N/A
IUPHAR	1876
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	398.107 nM	PMID12721327	IUPHAR

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