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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	Vilazodone
Molecular formula	C26H27N5O2
IUPAC name	5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
Molecular weight	441.535
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.0
Synonyms	AJ-26849 BCP05225 D0X6BV FT-0675813 PB25213 ST24044194 Vilazodone [USAN:INN] 5 -(4-(4-(5 -Cyano-1H-indol-3 -yl)butyl)piperazin-1 -yl)benzofuran-2-carboxamide 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide AN-489 EMD 515259 HY-14262 S239O2OOV3 vilazodona yl}-1-benzofuran-2-carboxamide 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide AC-25886 AX8156424 CTK8C0046 EX-A174 MolPort-005-933-319 SCHEMBL650682 Vilazodone (USAN/INN) 163521-12-8 5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide AK-61011 BDBM50151982 GTPL7427 Q-4354 TC-152681 vilazodonum 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide 5-{4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl}benzo-furan-2-carboxamide AB0044260 ANW-63936 CHEMBL439849 EMD-515259 KB-62239 SB-659746-A ZINC1542113 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide AC1OCFA2 BC203239 D09698 F0001-2418 NCGC00371130-06 SGEGOXDYSFKCPT-UHFFFAOYSA-N Vilazodone [INN] 4CA-1322 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1- AKOS015924744 CHEBI:70707 DB06684 HSDB 8197 QCR-275 UNII-S239O2OOV3 Y1282 5-(4-(4-(5-Cyanoindol-3-yl)butyl)-1-piperazinyl)-2-benzofurancarboxamide AB01563299_01 API0008118 CS-0550 EMD-68-843 L001518 SB20296 Vilazodone (TN) 1-[4-(5-cyanoindol-3-yl)butyl]4-(2-carbamoyl-benzofuran-5-yl)-piperazine 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide [ Show all ]
Inchi Key	SGEGOXDYSFKCPT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
PubChem CID	6918314
ChEMBL	CHEMBL439849
IUPHAR	7427
BindingDB	50151982
DrugBank	DB06684
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	252.0 nM	PMID15341484	IUPHAR

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