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GPCR

Name	B2 bradykinin receptor
Species	Mus musculus (Mouse)
Gene	Bdkrb2
Synonym	B2 receptor B2BKR B2BRA B2R BK-2 receptor BK2R bradykinin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	392
Amino acid sequence	MPCSWKLLGFLSVHEPMPTAASFGIEMFNVTTQVLGSALNGTLSKDNCPDTEWWSWLNAIQAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMREYSEEGHNVTACVIVYPSRSWEVFTNVLLNLVGFLLPLSVITFCTVRILQVLRNNEMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTFLDTLLRLGVLSGCWDEHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGEPVQMENSMGTLRTSISVERQIHKLQDWAGKKQ
UniProt	P32299
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	42
DrugBank	N/A

Ligand

Name	Npc-567
Molecular formula	C60H87N19O13
IUPAC name	(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular weight	1282.48
Hydrogen bond acceptor	17
Hydrogen bond donor	17
XlogP	-5.9
Synonyms	LS-186858 BDBM50435301 CHEMBL446325 D-Arg-[Hyp3, D-Phe7]-Bradykinin Bradykinin, arg-hyp(3)-phe(7)- DV64B0PLEH [D-Arg0,Hyp3,D-Phe7]bradykinin arg(0)-hyp(3)-phe(7)-bradykinin CHEBI:73294 LS-187514 (D-ARG0,HYP3,D-PHE7)-BRADYKININ BIM 31006 D-Arg-(Hyp3,D-Phe7)bradykinin D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-L-arginine UNII-DV64B0PLEH Bradykinin, arginyl-hydroxyprolyl(3)-phenylalanine(7)- GTPL676 Arg-3-hyp-7-phe-bradykinin Npc 567 109333-26-8 Bradykinin, arg(0)-hyp(3)-phe(7)- D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg D03ZBM [D-Arg(0),Hyp(3),D-Phe(7)]bradykinin AC1L3OMW Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-D-phenylalanine- [ Show all ]
Inchi Key	RBIXVHPHNGXTCI-QJTYZATASA-N
Inchi ID	InChI=1S/C60H87N19O13/c61-39(20-10-24-68-58(62)63)49(83)73-40(21-11-25-69-59(64)65)55(89)78-27-13-23-46(78)56(90)79-33-38(81)31-47(79)54(88)71-32-48(82)72-42(28-35-14-4-1-5-15-35)50(84)77-45(34-80)53(87)76-44(30-37-18-8-3-9-19-37)52(86)75-43(29-36-16-6-2-7-17-36)51(85)74-41(57(91)92)22-12-26-70-60(66)67/h1-9,14-19,38-47,80-81H,10-13,20-34,61H2,(H,71,88)(H,72,82)(H,73,83)(H,74,85)(H,75,86)(H,76,87)(H,77,84)(H,91,92)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70)/t38-,39-,40+,41+,42+,43+,44-,45+,46+,47+/m1/s1
PubChem CID	119343
ChEMBL	CHEMBL446325
IUPHAR	676
BindingDB	50435301
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.99526 nM	PMID8302267	IUPHAR

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