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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	dinoprost
Molecular formula	C20H34O5
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.7
Synonyms	Dinoprostum [INN-Latin] GTPL1884 (+)-Prostaglandin F2alpha HY-12956 (5z,9alpha,11alpha,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid NCGC00160385-02 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (+-)- PGF2 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid Prosta-10,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S) AC1NQWY5 Prostaglandin F2.alpha. BRN 4153898 Prostin F2alpha CHEBI:15553 SR-01000946457-1 U-14,583 Dinoprost (JP17/USAN/INN) DSSTox_GSID_22946 HMS1989K16 (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate l-Prostaglandin F2-alpha (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid NCGC00160385-06 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, l- PGF2-alpha racemic mixt. 99437-94-2 Prostaglandin F(sub 2a) AN-796 Prostaglandin F2alpha, dl- C20H34O5 SCHEMBL24292 CP0104 Y0222 Dinoprosta [INN-Spanish] Enzaprost ( )-Prostaglandin F2alpha HMS3648N11 (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid MolPort-005-940-967 PDSP2_000079 62P015 PGF2alpha 9alpha,11beta-PGF2 Prostaglandin F2-alpha BML1-F08 Prostin F 2 alpha CCRIS 4253 SR-01000721847-4 D00081 DB12789 dl-Prostaglandin F2-alpha HMS1361K16 (+-)-PGF2-alpha IDI1_033964 (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid NCGC00160385-04 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (1R-(1alpha(Z),2beta(S*,E),3alpha,5alpha))- PGF2 alpha 9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-(+-)- (9CI) AKOS030526160 Prostaglandin F2a BSPBio_001494 Protamodin Tox21_111777 U-14583 Dinoprost [USAN:INN:BAN:JAN] DSSTox_RID_76800 HMS2089F11 (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid LMFA03010002 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(E)-(3S)-3-hydroxy-1-octenyl}-cyclopentyl]-5-heptenoic acid P1885 PGF2.alpha. 9a,11a-PGF2 Prostaglandin F2 B7IN85G1HY Prostaglandin F2\|A CAS-551-11-1 SR-01000721847 CS-4232 D00HTY ZINC3830709 Dinoprostum Enzaprost F (+)-Prostaglandin F2a HSDB 3315 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoate NCGC00160385-01 23518-25-4 PGF-2alpha 7-(3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid Prosmon (TN) 9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid Prostaglandin F2-alpha, racemic mixt. BRN 2225571 Prostin F2-alpha Cerviprost SR-01000946457 DSSTox_CID_2946 HMS1791K16 (+-)-PGF2alpha l-PGF2-alpha (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid NCGC00160385-05 5-HEPTENOIC ACID, 7-(3,5-DIHYDROXY-2-(3-HYDROXY-1-OCTENYL)CYCLOPENTYL)-, dl- PGF2-alpha 9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)- amoglandin prostaglandin F2alpha C00639 PXGPLTODNUVGFL-YNNPMVKQSA-N CHEMBL815 U 14583 UNII-B7IN85G1HY Dinoprosta DTXSID9022946 HMS3402K16 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-3,13-dien-1-oic acid LS-125835 13535-33-6 panacelan 551-11-1 PGF2a 9alpha,11alpha-PGF2 Prostaglandin F2 alpha BDBM50035622 Prostarmon F CCG-208257 SR-01000721847-2 cyclosin [ Show all ]
Inchi Key	PXGPLTODNUVGFL-YNNPMVKQSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
PubChem CID	5280363
ChEMBL	CHEMBL815
IUPHAR	1884
BindingDB	50035622
DrugBank	DB12789
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	630.957 nM	PMID9537820	IUPHAR

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