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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Mus musculus (Mouse)
Gene	Htr1b
Synonym	HTR1D2 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 5-HT1Dbeta 5-HT1DB 5-HT1B serotonin receptor 5-HT1B receptor 5-HT1B 5-HT-1B serotonin receptor 1B [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
UniProt	P28334
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3708691
IUPHAR	2
DrugBank	N/A

Ligand

Name	5-OH-Dpat
Molecular formula	C16H25NO
IUPAC name	6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	(-)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol BDBM50020221 D00QHR 2-Dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol L000957 5-Hydroxy-2-N,N-dipropylaminotetralin 68593-96-4 1-Naphthalenol, 6-(dipropylamino)-5,6,7,8-tetrahydro- D0H3KU 5-Hydroxy-2-(di-n-propylamino)tetralin 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (DP-5-ADTN) SCHEMBL279021 (-)-5-hydroxy-2-(dipropylamino)tetralin 5-hydroxy-N,N-dipropyl-2-aminotetralin AC1L58V4 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol CHEMBL273273 GTPL128 5-hydroxy-2-(dipropylamino)tetralin 6-dipropylaminotetralin-1-ol [ Show all ]
Inchi Key	MDBWEQVKJDMEMK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3
PubChem CID	172267
ChEMBL	CHEMBL273273
IUPHAR	128
BindingDB	50020221
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3.98107 nM	PMID1557407	IUPHAR

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