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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 14
Species	Rattus norvegicus (Rat)
Gene	P2ry14
Synonym	UDP-glucose receptor purinergic receptor P2Y P2Y14 receptor P2Y14 P2Y purinoceptor 14 GPR105 G-protein coupled receptor 105 G protein-coupled receptor 105 G protein coupled receptor for UDP-glucose VTR 15-20 [ Show all ]
Disease	N/A for non-human GPCRs
Length	305
Amino acid sequence	MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS
UniProt	O35881
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	330
DrugBank	N/A

Ligand

Name	UDP-N-acetylglucosamine
Molecular formula	C17H27N3O17P2
IUPAC name	[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight	607.355
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.6
Synonyms	Uridine diphospho-N-acetyl-D-glucosamine URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE (2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) DB03397 UDP N-acetyl-glucosamine UDP-N-acetyl-alpha-D-glucosamine Uridine 5'-diphospho-N-acetylglucosamine Uridine diphosphoacetylglucosamine [[3-acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinate 91183-98-1 LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-acetyl-delta-glucosamine UDP-N-acetyl-glucosamine Uridine diphosphate N-acetyl-delta-glucosamine Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-delta-glucopyranosyl ester CHEBI:16264 UD1 UDP-alpha-delta-N-acetylglucosamine UPPAG Uridine diphospho-2-acetamido-2-deoxy-D-glucose Uridine diphospho-N-acetyl-delta-glucosamine ZINC8551100 GTPL1779 UDP-a-D-N-acetylglucosamine UDP-N-acetyl-D-glucosamine uridine 5'-[3-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl) dihydrogen diphosphate] Uridine pyrophosphate 2-acetamido-2-deoxy-a-D-glucopyranosyl ester [[3-acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinic acid AC1L9IDL N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide UDP-acetylglucosamine uridine diphosphate N-acetylglucosamine Uridine diphospho-2-acetamido-2-deoxy-delta-glucose uridine-diphosphate-n-acetylgalactosamine D0KC2Z UD2 UDP-GlcNAc Uridine 5'-Diphospho-N-Acetlyglucosamine Uridine diphospho-N-acetylglucosamine [(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate 528-04-1 J-700272 UDP-acetyl-D-glucosamine UDP-N-acetyl-delta-glucosamine Uridine diphosphate N-acetyl-D-glucosamine Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-D-glucopyranosyl ester {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid C00043 SCHEMBL1521296 UDP-alpha-D-N-acetylglucosamine Udpx Uridine diphosphate-N-acetylglucosamine [ Show all ]
Inchi Key	LFTYTUAZOPRMMI-CFRASDGPSA-N
Inchi ID	InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1
PubChem CID	445675
ChEMBL	N/A
IUPHAR	1779
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	158.489 nM	PMID11735218	IUPHAR

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