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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Hcar1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	343
Amino acid sequence	MDNGSCCLIEGEPISQVMPPLLILVFVLGALGNGIALCGFCFHMKTWKSSTIYLFNLAVADFLLMICLPLRTDYYLRRRHWIFGDIACRLVLFKLAMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAISNRTAAATACVLWTLVILGTVYLLMESHLCVQGTLSSCESFIMESANGWHDVMFQLEFFLPLTIILFCSVNVVWSLRRRQQLTRQARMRRATRFIMVVASVFITCYLPSVLARLYFLWTVPTSACDPSVHTALHVTLSFTYLNSMLDPLVYYFSSPSLPKFYTKLTICSLKPKRPGRTKTRRSEEMPISNLCSKSSIDGANRSQRPSDGQWDLQVC
UniProt	Q8C131
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2146354
IUPHAR	311
DrugBank	N/A

Ligand

Name	L-Lactic acid
Molecular formula	C3H6O3
IUPAC name	(2S)-2-hydroxypropanoic acid
Molecular weight	90.078
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-0.7
Synonyms	L(+)-Lacticacid L-(+)-Lactic acid solution, meets analytical specification of Ph.??Eur., BP, 88-92% total acid basis L-(+)-Lactic acid, anhydrous (S)-2-hydroxy-propionic acid L-Lactic acid homopolymer (\|A)-lactate LS-87453 PH 90 Acidum sarcolacticum Propanoic acid, 2-hydroxy-, (S)-, homopolymer BRN 1720251 Tisulac EC 201-196-2 HY-Y0479 L-(+)-alpha-Hydroxypropionic acid L-(+)-Lactic acid solution, ~40% in H2O (2S)-2-hydroxypropanoic acid L-0990 (S)-2-Hydroxypropionsaeure L-Milchsaeure 1715-99-7 MolPort-003-848-345 5E39D33D-2F71-4C24-BC7A-5E6F27E4CF83 Poly(lactic acid) Atrisorb Sarcolactic acid CHEMBL330546 UNII-F9S9FFU82N F9S9FFU82N L( )-2-Hydroxypropionsaeure L-(+)-Lactic acid solution, ACS reagent, 85-90% (L-lactic acid in water) L-(+)-Lactic acid, >=98% (S)(+)2 hydroxypropionic acid L-lactate (S)-Lactic acid Lactic Acid FCC 26811-96-1 Paralactic acid AC1Q29M6 PROPANOIC ACID, 2-HYDROXY-, (S)- bmse000818 Sculptra DL6049 W92NDP347A FT-0774042 L(+)-Lactic acid, 20 wt.% solution in water L-( pound<<)-Lactic acid L-(+)-Lactic acid solution, purum p.a., 79-81% (L-lactic acid in water, T) (+)-Lactic acid L-(+)-Lactic acid, BioXtra, >=98% (titration) (S)-2-Hydroxypropanoic acid L-Lactic acid solution, 90.0% 133520-50-0 MCULE-8864689875 2OP Pleo sanvis AJ-51840 PURAC C00186 UNII-3B8D35Y7S4 component JVTAAEKCZFNVCJ-REOHCLBHSA-N EINECS 201-196-2 JVTAAEKCZFNVCJ-REOHCLBHSA-N L-(+)-Lactic acid L-(+)-Lactic acid solution, ~50% (L-lactic acid in water) (2S)-2-Hydroxypropanoic acid homopolymer L-1000 (S)-2-oC>>u+/-uEa l-milchsaure 2-Hydroxypropanoic acid, (S)- # nchembio867-comp9 79-33-4 Poly-L-lactic acid BC207702 Sarcolacticum acidum CS-0015266 UNII-W92NDP347A Fleischmilchsaeure L(+)-2-Hydroxypropionsaeure L-(+)-Lactic acid solution, in H2O, >=85% L-(+)-Lactic acid, analytical standard (S)-(+)-Lactic acid (S)-Milchsaeure Lactic acid, L- 26813-65-0 Paramilchsaeure AC1Q5QUL Propanoic acid, 2-hydroxy-, (S)- (9CI) bmse000979 Ticron DTXSID6034689 ZINC4658560 GTPL2932 L(+)-Lactic acid, 90% solution in water L-(+) Lactic Acid L-(+)-Lactic acid solution, purum, ~20% (L-lactic acid in water) (1/4) inverted exclamation markEeEa L-(+)-Lactic acid, Vetec(TM) reagent grade, 86% (S)-2-Hydroxypropionic acid L-Lactic acid, crystalline, 98.0%+ 1417904-05-2 MFCD00064266 4-03-00-00633 (Beilstein Handbook Reference) PLLA AKOS025146504 S-Lactic acid sodium salt CHEBI:422 UNII-3B8D35Y7S4 component JVTAAEKCZFNVCJ-UWTATZPHSA-N Espiritin KS-00000WTK L-(+)-Lactic acid solution, 30% in H2O (by weight) L-(+)-Lactic acid, 80% (s)(+)-2 hydroxypropionic acid L-Iactic acid (S)-lactate L0165 204379-14-6 New-Fill AC1L32K7 Propanoic acid, 2-hydroxy-, (2S)- bmse000208 SC-18207 D06FZS V3455 FT-0773848 L(+)-LACTIC ACID [ Show all ]
Inchi Key	JVTAAEKCZFNVCJ-REOHCLBHSA-N
Inchi ID	InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
PubChem CID	107689
ChEMBL	N/A
IUPHAR	2932
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1513560.0 - 6760830.0 nM	PMID19047060, PMID20374963	IUPHAR

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