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GPCR

Name	Metabotropic glutamate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Grm1
Synonym	mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl GPRC1A glutamate receptor, metabotropic 1 glutamate receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	1199
Amino acid sequence	MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
UniProt	P23385
Protein Data Bank	1iss, 1isr, 1ewk
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 1iss.
BioLiP	BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4477
IUPHAR	289
DrugBank	N/A

Ligand

Name	(S)-MCPG
Molecular formula	C10H11NO4
IUPAC name	4-[(1S)-1-amino-1-carboxyethyl]benzoic acid
Molecular weight	209.201
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-2.0
Synonyms	4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID alpha-Methyl-4-carboxyphenylglycine CHEMBL257626 GTPL1373 NCGC00015676-02 SR-01000597608 (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic (S)-4-(1-amino-1-carboxyethyl)benzoic acid Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (alphaS)- D06ALU Lopac-M-4796 NCGC00024543-02 Tocris-0337 (+)-alpha-Methyl-4-carboxyphenylglycine AKOS024457587 CHEBI:43876 DB04256 MolPort-003-958-661 S(+)-\|A-Amino-4-carboxy-\|A-methyl-benzeneacetic acid ZINC2559035 (+)-\|A-Methyl-4-carboxyphenylglycine (S)-(+)-alpha-methyl-4-carboxyphenylglycine 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid alpha-Methyl-cpgly CS-5944 HY-100406 NCGC00024542-01 SR-01000597608-1 (S)-?-Methyl-4-carboxyphenylglycine 61F6J48NHR Benzeneacetic acid,a-amino-4-carboxy-a-methyl-,(as)- D0J8OW MCG RT-005746 UNII-61F6J48NHR (+)-alpha-Methyl-4-carboxyphenylglycine, solid alpha-Mcpg DTXSID2042567 NCGC00015676-01 SCHEMBL12648649 (R,S)-MCPG (S)-(ALPHA)-METHYL-4-CARBOXYPHENYLGLYCINE 4-[(2S)-2-amino-1-hydroxy-1-oxopropan-2-yl]benzoic acid BDBM50212325 CTK8F0682 J-008664 NCGC00024543-01 Tocris-0336 (S)-a-methyl-4-carboxyphenylglycine AC1L9JKC BN0323 MFCD00216858 S(+)-alpha-Amino-4-carboxy-alpha-methyl-benzeneacetic acid UNII-7HJ67IIE31 component DNCAZYRLRMTVSF-JTQLQIEISA-N (+)-MCPG [ Show all ]
Inchi Key	DNCAZYRLRMTVSF-JTQLQIEISA-N
Inchi ID	InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
PubChem CID	446355
ChEMBL	CHEMBL257626
IUPHAR	1373
BindingDB	50212325
DrugBank	DB04256
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	158489.0 nM	PMID12695537	IUPHAR

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