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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Trhr
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	N/A for non-human GPCRs
Length	412
Amino acid sequence	MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
UniProt	Q01717
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4553
IUPHAR	363
DrugBank	N/A

Ligand

Name	midazolam
Molecular formula	C18H13ClFN3
IUPAC name	8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
Molecular weight	325.771
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.5
Synonyms	Dormicum HSDB 6751 Midazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Ro 21-3981 ZINC95626706 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine BDBM21363 CHEMBL655 D0U6LM DTXSID5023320 Hypnovel (TN) Midazolam 0.1 mg/ml in Methanol Midazolamum UNII-R60L0SM5BC 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate ACN-036275 Buccolam DDLIGBOFAVUZHB-UHFFFAOYSA-N FT-0672402 Midacum (TN) Midazolam hydrochloride, solid NCGC00168254-01 Versed (Salt/Mix) 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin API0003385 C18H13ClFN3 Dormicum (TN) HY-B0676 Midazolam (JAN/INN) Midazolam [INN:BAN:JAN] SCHEMBL35061 467M640 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine BIDD:GT0647 CS-2907 Dazolam EINECS 261-774-5 LS-77780 Midazolam 1.0 mg/ml in Methanol Midazolamum [INN-Latin] USL261 08J 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl- AKOS015842580 Buccolam (TN) DEA No. 2884 GTPL3342 Midanium Midazolam hydrochloride, United States Pharmacopeia (USP) Reference Standard R60L0SM5BC Versed (TN) 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,8,10,12-hexaene 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine BCP21296 CHEBI:6931 D00550 Dormonid (Salt/Mix) Hypnovel (Salt/Mix) Midazolam (JAN/USP/INN) Midazolam [USP:INN:BAN:JAN] TL8003787 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl- AC1L1HMA BRN 0625572 DB00683 Flormidal (Salt/Mix) mezolam Midazolam Base Midosed Versed 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0;{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene 59467-70-8 AN-39557 C07524 [ Show all ]
Inchi Key	DDLIGBOFAVUZHB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
PubChem CID	4192
ChEMBL	N/A
IUPHAR	3342
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3200.0 nM	PMID2566295	IUPHAR

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