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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	cis-Epoxysuccinic acid
Molecular formula	C4H4O5
IUPAC name	(2R,3S)-oxirane-2,3-dicarboxylic acid
Molecular weight	132.071
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	-0.9
Synonyms	E0449 NCGC00096635-01 AC1MC1YT cis-2,3-Oxiranedicarboxylic acid GTPL9631 W-200155 Cis-oxirane-2,3-dicarboxylic acid NCGC00013522 2,3-Oxiranedicarboxylic acid, (2R,3S)-rel- FT-0605454 NSC-43234 AKOS005258282 KB-49056 ZINC1675960 (2R,3S)-oxirane-2,3-dicarboxylic acid DCEMCPAKSGRHCN-XIXRPRMCSA-N NCGC00013522-02 GEO-01295 SCHEMBL4466386 CHEMBL1741775 cis-Epoxysuccinic acid, 97% MolPort-006-109-370 16533-72-5 [ Show all ]
Inchi Key	DCEMCPAKSGRHCN-XIXRPRMCSA-N
Inchi ID	InChI=1S/C4H4O5/c5-3(6)1-2(9-1)4(7)8/h1-2H,(H,5,6)(H,7,8)/t1-,2+
PubChem CID	2734802
ChEMBL	N/A
IUPHAR	9631
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2700.0 nM	PMID28160606	IUPHAR

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