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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	D-phenylalanine
Molecular formula	C9H11NO2
IUPAC name	(2R)-2-amino-3-phenylpropanoic acid
Molecular weight	165.192
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-1.5
Synonyms	COLNVLDHVKWLRT-MRVPVSSYSA-N UNII-8P946UF12S component COLNVLDHVKWLRT-MRVPVSSYSA-N D-alpha-Amino-beta-phenylpropionic acid D0B3LN GTPL5797 KBio1_000453 (2R)-2-amino-3-phenyl-propanoic acid l-3-phenylalanine 1315049-39-8 NCI-C60195 AB00052351_03 Phenylalanine,(S) AC1Q5R0M SC-09765 ANW-35319 Spectrum_001725 ST2414214 D-(+)-Phenylalanine DPhe HMS1922C08 KBio2_007341 (R)-2-AMINO-3-PHENYLPROPANOIC ACID M02934 4C53B247-2FE4-4464-92C0-9F3782A08966 NSC-758460 AB1003067 Q-101646 AK-36068 SPBio_001436 C02265 TL8004742 D-2-Amino-3-phenylpropionic acid D-Phenylalanine, >=99% EN300-60166 J-300203 KS-00000A8W 032K16VRCU MolPort-001-757-416 73P063 Pharmakon1600-01503391 AC1L2GF3 Sabiden AM83526 Spectrum4_000865 CHEBI:16998 CS-W020009 Z1696844707 D-Phe DB02556 H-D-Phe-OH KBio2_002205 (2R)-2-amino-3-phenylpropanoic acid LS-1571 156896-EP2284178A2 NINDS_000453 AB0007201 Phenylalanine,d- ACT08578 SC-10967 AS-11997 SR-01000872765 SY005120 D-.beta.-Phenyl-.alpha.-alanine D-Phenylalanine, 99+% DTXSID4025876 HMS501G15 KBioGR_001529 (R)-2-Amino-3-phenylpropionic acid MCULE-2197316791 NSC758460 AC-11292 RTC-063928 AKOS007930513 SPECTRUM1503391 CCG-39336 CHEMBL379630 UNII-032K16VRCU D-alpha-Amino-beta-phenyl-propionic acid D-Phenylalanine, Vetec(TM) reagent grade, >=98% FT-0605139 KB-50431 KSC355E0T 10549-11-8 NCGC00163338-01 AB00052351_02 Phenylalanine D-form AC1Q4UAT SBI-0051820.P002 AN-7785 Spectrum5_001137 CTK2F5209 ZINC1927 d-phenylalanin DivK1c_000453 HDPheOH KBio2_004773 (D)-Phenylalanine M-6208 156896-EP2284179A2 NSC 25005 AB00345 PubChem10975 AJ-08112 SCHEMBL92744 BDBM36161 SR-01000872765-1 TC-063928 D-.beta.-Phenylalanine D-Phenylalanine, >=98% (HPLC) EINECS 211-603-5 IDI1_000453 KBioSS_002205 (R)-PHENYLALANINE MFCD00004270 673-06-3 P0135 AC-8664 s4153 Alanine, phenyl-, D- Spectrum2_001558 CCRIS 6267 [ Show all ]
Inchi Key	COLNVLDHVKWLRT-MRVPVSSYSA-N
Inchi ID	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1
PubChem CID	71567
ChEMBL	N/A
IUPHAR	5797
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	9020.0 nM	PMID19237584	IUPHAR

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